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See how Context works →On the price, the facts of the public record■Insider buy□Insider sell●Results filed
With an account, also○dividends▲splits◌next earningswith an account
End-of-day prices provided by Twelve Data · One close per session; the series does not update during the trading day.
Latest on record
The most recent facts, as filed.
Up to three of the most recent, checkable facts already loaded on this page, each linked to its source.
- Sep 16, 2026Reported sale · Form 4Allison Ambrose, General Counsel · $2.7KOpen the filing ↗
- Sep 16, 2026Reported sale · Form 4MICHAEL GRAY, CFO and COO · $4.7KOpen the filing ↗
- Sep 16, 2026Reported sale · Form 4Adam Houghton, Chief Business Officer · $3.8KOpen the filing ↗
In numbers
What this profile holds, counted.
Closes · 1 year250
SEC filings on record11811 flagged findings
Reported transactions (Form 4)72since Oct 10, 2024 · and 29 other holdings
Corporate events (8-K)1since Mar 26, 2026
What the record says
Description, identity and filings, each with its source.
Every block cites its source. The colour of a finding marks its category — which document, who filed it — not how much it matters.
The 25 most recent filings (of 118)
Every SEC filing, newest first, with what it is. Below, each type with its own explanation.
- Sep 1, 268-K ↗Current report · Communication to the market · Other events
- Aug 12, 26SCHEDULE 13G/A ↗Passive stake · Norges Bank · 7.7% · event on Jun 30, 26 · amendment
- Aug 11, 2610-Q ↗Quarterly report
- Aug 11, 268-K ↗Current report · Results
- Jul 30, 26SCHEDULE 13G ↗Passive stake · BlackRock, Inc. · 5.2% · event on Jun 30, 26
Insider transaction · 11 Form 4 filingsshow all 11hide
- Jun 17, 26Form 4 ↗Insider transaction
- Jun 17, 26Form 4 ↗Insider transaction
- Jun 17, 26Form 4 ↗Insider transaction
- Jun 17, 26Form 4 ↗Insider transaction
- Jun 17, 26Form 4 ↗Insider transaction
- Jun 11, 26Form 4 ↗Insider transaction
- Jun 11, 26Form 4 ↗Insider transaction
- Jun 11, 26Form 4 ↗Insider transaction
- Jun 11, 26Form 4 ↗Insider transaction
- Jun 11, 26Form 4 ↗Insider transaction
- Jun 11, 26Form 4 ↗Insider transaction
- Jun 10, 268-K ↗Current report · Shareholder vote results
- May 15, 26SCHEDULE 13G/A ↗Passive stake · Decheng Capital Global Life Sciences Fund IV, L.P. · 5.0% · event on Mar 31, 26 · amendment
- May 13, 2610-Q ↗Quarterly report
- May 13, 268-K ↗Current report · Results
118 filings on record, the oldest from Jul 9, 24.
Listing the 25 most recent filings of the 118 on record.
1
- Mar 26, 26Entered a material agreement+1 more in the same filing8-K 1.01 ↗
Corporate events are tracked from 2004-08-23, when the SEC renumbered 8-K items. Earlier filings use an incompatible numbering and are not classified here.
Schedule 13G: short-form filing
The short form, for holders who meet specific requirements: institutional investors, passive investors without a control purpose, or exempt investors. Asset managers and index funds usually file it.
- FMR LLC14.8%Jun 30, 25SCHEDULE 13G/A ↗2 co-filers on this document — the figure is the largest single stake, not their sum. · 1 earlier filing
- Norges Bank7.7%Jun 30, 26SCHEDULE 13G/A ↗1 earlier filing
- Xiangmin Cui6.1%Dec 31, 24SCHEDULE 13G ↗5 co-filers on this document — the figure is the largest single stake, not their sum.
- BlackRock, Inc.5.2%Jun 30, 26SCHEDULE 13G ↗
- Decheng Capital Global Life Sciences Fund IV, L.P.5.0%Mar 31, 26SCHEDULE 13G/A ↗5 co-filers on this document — the figure is the largest single stake, not their sum.
show 2 more holdershide
- HBM Healthcare Investments (Cayman) Ltd.4.1%Sep 30, 25SCHEDULE 13G/A ↗1 earlier filing
- TCG Crossover GP I, LLC3.9%Sep 30, 25SCHEDULE 13G/A ↗3 co-filers on this document — the figure is the largest single stake, not their sum. · 1 earlier filing
Structured 13D/G data starts 2023-12, when the SEC moved these filings to a machine-readable format. Earlier filings exist but are not parsed here.
- Sep 16, 26Sell$3KAllison AmbroseGeneral Counsel↗
- Sep 16, 26Sell$5KMICHAEL GRAYCFO and COO↗
- Sep 16, 26Sell$4KAdam HoughtonChief Business Officer↗
- Sep 16, 26Sell$12KEverett Rand SutherlandChief Executive Officer↗
- Sep 16, 26Sell$5KAaron DeykinChief Medical Officer↗
- Jun 16, 26Sell$3KAllison AmbroseGeneral Counsel↗
- Jun 16, 26Sell$5KAaron DeykinChief Medical Officer↗
- Jun 16, 26Sell$4KAdam HoughtonChief Business Officer↗
- Jun 16, 26Sell$13KEverett Rand SutherlandChief Executive Officer↗
- Jun 16, 26Sell$5KMICHAEL GRAYCFO and COO↗
- Mar 16, 26Sell$6KAdam HoughtonChief Business Officer↗
- Mar 16, 26Sell$4KAllison AmbroseGeneral Counsel↗
There are 8 more transactions in this stretch.
Stock compensation, tax and giftsshow the 12 other transactionshide
Stock compensation, tax withholding, option exercises and gifts. They are listed separately and are not included in the purchase and sale totals. The type describes the transaction, not the filer's intent.
- Jan 2, 26Compensationamount n/aEverett Rand SutherlandChief Executive Officer↗
- Jan 2, 26Compensationamount n/aAdam HoughtonChief Business Officer↗
- Jan 2, 26Compensationamount n/aAllison AmbroseGeneral Counsel↗
- Jan 2, 26Compensationamount n/aAaron DeykinChief Medical Officer↗
- Jan 2, 26Compensationamount n/aMICHAEL GRAYCFO and COO↗
- Oct 15, 24Otheramount n/aWellington Biomedical Innovation Master Investors (Cayman) II L.P.↗
- Oct 15, 24Otheramount n/aORBIMED ADVISORS LLC↗
- Oct 15, 24Otheramount n/aORBIMED ADVISORS LLC↗
- Oct 15, 24Otheramount n/aErez Chimovits↗
- Oct 15, 24Otheramount n/aErez Chimovits↗
- Oct 15, 24Otheramount n/aAI Upstream LLC↗
- Oct 15, 24Otheramount n/aAI Upstream LLC↗
The full record holds 32 transactions and goes back to Oct 10, 24.
Its sector and its market
Upstream Bio, Inc. among Health Care companies
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- 118 documents on file, from Jul 9, 2024 to Sep 17, 2026.
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