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See how Context works →On the price, the facts of the public record■Insider buy□Insider sell◇Significant stake declared (13D)●Results filed
With an account, also○dividends▲splits◌next earningswith an account
End-of-day prices provided by Twelve Data · One close per session; the series does not update during the trading day.
Latest on record
The most recent facts, as filed.
Up to three of the most recent, checkable facts already loaded on this page, each linked to its source.
- Oct 7, 2026Material event · 8-KFiled by the company itself.Open the filing ↗
- Oct 1, 2026Reported sale · Form 4Scott L Burrows, Chief Financial Officer · $53.4KOpen the filing ↗
- Oct 1, 2026Reported sale · Form 4Scott L Burrows, Chief Financial Officer · $135.4KOpen the filing ↗
In numbers
What this profile holds, counted.
Closes · 1 year250
SEC filings on record76922 flagged findings
Reported transactions (Form 4)80since Jan 15, 2025 · and 15 other holdings
Corporate events (8-K)30since Jul 14, 2023
What the record says
Description, identity and filings, each with its source.
Every block cites its source. The colour of a finding marks its category — which document, who filed it — not how much it matters.
Identity
Formerly traded as AGLE.
Regulatory history
Topics detected in its SEC reports, with the original excerpt.
Each topic is assigned by a classifier over the full filing; the excerpts show where it was detected and are not always enough to verify it. Open the filing to read it in full.
- 2026-05-05share offering or dilution eventrecentOpen filing ↗“…) The accompanying notes are an integral part of these condensed consolidated financial statements. 3 Spyre Therapeutics, Inc.…”
+1 more passage from the same document
- “…vest and become exercisable in 36 equal monthly installments, subject to Mr. McKenna’s continued service to the Company…”
- 2026-05-05listing compliance noticerecentOpen filing ↗“…and financial compliance costs and causes management and other personnel to divert attention from operational and other business…”
- 2026-04-16share offering or dilution eventrecentOpen filing ↗“…to sell, pledge, contract to sell, sell any option or contract to purchase, purchase any option or contract to sell, grant any…”
+1 more passage from the same document
- “…commitment as indicated in the table above. No Sales of Similar Securities We and our executive officers and directors have…”
- 2026-04-16capital return (buybacks/dividends)recentOpen filing ↗“…the amount of debt securities of such series whose holders must consent to an amendment, supplement or waiver; • reduce the rate of…”
- 2026-04-13share offering or dilution eventrecentOpen filing ↗“…to sell, pledge, contract to sell, sell any option or contract to purchase, purchase any option or contract to sell, grant any…”
+1 more passage from the same document
- “…commitment as indicated in the table above. No Sales of Similar Securities We and our executive officers and directors have…”
- 2026-04-13capital return (buybacks/dividends)recentOpen filing ↗“…the amount of debt securities of such series whose holders must consent to an amendment, supplement or waiver; • reduce the rate of…”
Original excerpts from SEC filings, untranslated. Not advice and not a prediction.
Reverse splits in 5 years
1 reverse split in 5 years (1:25 on Sep 8, 2023) · 1:25 cumulative
The other times: of 818 securities that did their first reverse split in 5 years, a year later the median was worth 0.53× the price on the day of the split; 382 lost more than half and 209 rose (809 with a price a year later).
Our own series, not the whole market: based on the splits we have on record (provider and SEC); an unrecorded one does not count. Historical distribution, not a prediction.
The 25 most recent filings (of 769)
Every SEC filing, newest first, with what it is. Below, each type with its own explanation.
- Oct 9, 26SCHEDULE 13D/A ↗Stake with intent to influence · Harwin Peter Evan · 10.0% · event on Oct 7, 26 · amendment
- Oct 7, 268-K ↗Current report · Entered a material agreement
- Oct 6, 26424B5 ↗Securities offering
- Oct 5, 26424B5 ↗Securities offering
Notice of proposed sale · 2 Form 144 filingsshow all 2hide
- Oct 1, 26Form 144 ↗Notice of proposed sale
- Oct 1, 26Form 144 ↗Notice of proposed sale
- Oct 1, 26SCHEDULE 13G ↗Passive stake · Paradigm BioCapital Advisors LP · 5.1% · event on Sep 24, 26
- Sep 30, 26Form 144 ↗Notice of proposed sale
- Sep 8, 268-K ↗Current report · Communication to the market · Other events
- Sep 1, 26Form 144 ↗Notice of proposed sale
- Aug 25, 268-K ↗Current report · Communication to the market · Other events
- Aug 14, 26SCHEDULE 13G/A ↗Passive stake · RTW Investments, LP · 4.8% · event on Jun 30, 26 · amendment
- Aug 14, 26SCHEDULE 13G/A ↗Passive stake · Perceptive Advisors LLC · 4.9% · event on Jun 30, 26 · amendment
- Aug 10, 26Form 4 ↗Insider transaction
Notice of proposed sale · 2 Form 144 filingsshow all 2hide
- Aug 7, 26Form 144 ↗Notice of proposed sale
- Aug 7, 26Form 144 ↗Notice of proposed sale
- Aug 4, 268-K ↗Current report · Results
769 filings on record, the oldest from Jun 3, 15.
Listing the 25 most recent filings of the 769 on record.
73432
- Oct 7, 26Entered a material agreement+1 more in the same filing8-K 1.01 ↗
- May 29, 26A senior executive left or was appointed+2 more in the same filing8-K 5.02 ↗
- Apr 16, 26Entered a material agreement+1 more in the same filing8-K 1.01 ↗
- Oct 15, 25Entered a material agreement+1 more in the same filing8-K 1.01 ↗
- Mar 6, 25Auditor change filing (8-K Item 4.01)+1 more in the same filing8-K 4.01 ↗
- Nov 19, 24Entered a material agreement+1 more in the same filing8-K 1.01 ↗
- Nov 18, 24Past accounts declared unreliable and being restated+1 more in the same filing8-K 4.02 ↗
- Oct 15, 24Entered a material agreement+3 more in the same filing8-K 1.01 ↗
- May 15, 24Entered a material agreement+5 more in the same filing8-K 1.01 ↗
- Apr 25, 24Sold unregistered shares+1 more in the same filing8-K 3.02 ↗
- Mar 18, 24Entered a material agreement+4 more in the same filing8-K 1.01 ↗
- Feb 5, 24Entered a material agreement+4 more in the same filing8-K 1.01 ↗
10 older filings not shown · The record reaches back to Feb 16, 17.
Stress disclosures older than the timeline above. They are individual events from the record, not a complete timeline: there may be more between them.
- Jan 18, 24Listing notice (8-K 3.01)8-K 3.01 ↗
- Sep 25, 23Listing notice (8-K 3.01)+3 more in the same filing8-K 3.01 ↗
- Jul 14, 23Listing notice (8-K 3.01)8-K 3.01 ↗
- Apr 12, 23Restructuring plan with committed costs+3 more in the same filing8-K 2.05 ↗
- Jan 18, 23Listing notice (8-K 3.01)8-K 3.01 ↗
- Jul 19, 22Listing notice (8-K 3.01)8-K 3.01 ↗
The full record holds 7 stress filings.
Corporate events are tracked from 2004-08-23, when the SEC renumbered 8-K items. Earlier filings use an incompatible numbering and are not classified here.
Schedule 13D: stake and stated purpose
Filed by holders above 5% of a share class who cannot use the short form. It includes the investor's stated purpose: read it before assuming they seek influence.
- Harwin Peter Evan10.0%Oct 7, 26SCHEDULE 13D/A ↗4 co-filers on this document — the figure is the largest single stake, not their sum.
- Peter Evan Harwin10.0%Jun 23, 26SCHEDULE 13D/A ↗4 co-filers on this document — the figure is the largest single stake, not their sum. · 1 earlier filing
- Peter Harwin10.0%Apr 16, 26SCHEDULE 13D/A ↗4 co-filers on this document — the figure is the largest single stake, not their sum.
Schedule 13G: short-form filing
The short form, for holders who meet specific requirements: institutional investors, passive investors without a control purpose, or exempt investors. Asset managers and index funds usually file it.
- BlackRock, Inc.6.6%Jun 30, 25SCHEDULE 13G/A ↗
- Paradigm BioCapital Advisors LP5.1%Sep 24, 26SCHEDULE 13G ↗4 co-filers on this document — the figure is the largest single stake, not their sum.
- The Vanguard Group5.1%Jun 30, 25SCHEDULE 13G ↗
- Perceptive Advisors LLC4.9%Jun 30, 26SCHEDULE 13G/A ↗3 co-filers on this document — the figure is the largest single stake, not their sum. · 2 earlier filings
- RTW Investments, LP4.8%Jun 30, 26SCHEDULE 13G/A ↗2 co-filers on this document — the figure is the largest single stake, not their sum. · 1 earlier filing
show 2 more holdershide
- Venrock Healthcare Capital Partners III, L.P.4.6%Dec 31, 24SCHEDULE 13G/A ↗7 co-filers on this document — the figure is the largest single stake, not their sum.
- TANG CAPITAL MANAGEMENT, LLC2.4%Dec 31, 25SCHEDULE 13G/A ↗6 co-filers on this document — the figure is the largest single stake, not their sum. · 1 earlier filing
Structured 13D/G data starts 2023-12, when the SEC moved these filings to a machine-readable format. Earlier filings exist but are not parsed here.
Sale intention announced
On Oct 1, CAMERON TURTLE filed notice of intent to sell up to $4.0M. That is about 0.05% of shares outstanding. It is filed under a scheduled plan (10b5-1), arranged in advance.
A notice is not a sale: it may not go ahead, may happen in part, or at a different price.
After the notice, they sold $1.4M across 6 trades on Oct 1, per their Form 4. That is 33% of the shares announced so far, and the window is still open.
View notice (Form 144) ↗+9 more recent notices · 8 with a later sale
- Oct 1, 26Sell$53KScott L BurrowsChief Financial Officer↗
- Oct 1, 26Sell$135KScott L BurrowsChief Financial Officer↗
- Oct 1, 26Sell$193KScott L BurrowsChief Financial Officer↗
- Oct 1, 26Sell$285KScott L BurrowsChief Financial Officer↗
- Oct 1, 26Sell$21KScott L BurrowsChief Financial Officer↗
- Oct 1, 26Sell$53KCameron TurtleChief Executive Officer↗
- Oct 1, 26Sell$242KCameron TurtleChief Executive Officer↗
- Oct 1, 26Sell$241KCameron TurtleChief Executive Officer↗
- Oct 1, 26Sell$368KCameron TurtleChief Executive Officer↗
- Oct 1, 26Sell$466KCameron TurtleChief Executive Officer↗
- Oct 1, 26Sell$9KCameron TurtleChief Executive Officer↗
- Oct 1, 26Sell$36KHeidy King-JonesSee Remarks↗
There are 21 more transactions in this stretch.
Stock compensation, tax and giftsshow the 7 other transactionshide
Stock compensation, tax withholding, option exercises and gifts. They are listed separately and are not included in the purchase and sale totals. The type describes the transaction, not the filer's intent.
- Oct 1, 26Compensation$109KScott L BurrowsChief Financial Officer↗
- Oct 1, 26Compensation$420KHeidy King-JonesSee Remarks↗
- Sep 30, 26Compensation$254KScott L BurrowsChief Financial Officer↗
- Sep 2, 26Compensation$6KHeidy King-JonesSee Remarks↗
- Sep 1, 26Compensation$109KScott L BurrowsChief Financial Officer↗
- Sep 1, 26Compensation$406KHeidy King-JonesSee Remarks↗
- Aug 7, 26Compensation$52KJeffrey W. Albers↗
The full record holds 130 transactions and goes back to Nov 14, 22.
Its sector and its market
Spyre Therapeutics, Inc. among Health Care companies
The profile shows what is on record. Context and Radar place the company among those of its sector and region.
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Coverage
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Where each figure comes from and how far it reaches.
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- End-of-day closes provided by Twelve Data. One close per session; not real time. Closes adjusted for splits.
- Series quality
- 250 clean closes in the period.
- SEC records
- 769 documents on file, from Jun 3, 2015 to Oct 9, 2026.
- Company description
- No description available.
- This page
- Generated on Oct 19, 2026; refreshed through the day.
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Are the prices real time?
No. It is one close per session, from the provider and with the date shown on the profile; it does not update during the trading day.
Which SEC documents appear here?
Those filed with the SEC by the company, its insiders and its major shareholders, within our coverage: periodic reports (10-K, 10-Q, 20-F), material events (8-K), proposed sale notices (Form 144), insider transactions (Form 4) and stakes above 5% (13D/13G). Each links to the original on EDGAR.
Why does a European company show no SEC records?
It depends on the company: some European issuers file a 20-F or 6-K with the SEC and others don't. The profile shows whatever is on record; when there is nothing, it says so rather than guessing why. Europe does not yet have a common filing archive like EDGAR in the United States. The EU will open its own, ESAP, in July 2027 (managers' transactions arrive in January 2028), and we plan to add it once it is available.
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